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KMID : 0603820150210020126
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Journal of Experimental & Biomedical Science
2015 Volume.21 No. 2 p.126 ~ p.130
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Insulin-like Growth Factor-1 (IGF-1) Gene Expression Is Enhanced under Hypothermia but Depressed under Additional Ischemic Stimulus
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Kwon O-Yu
Kwon Ki-sang
Yu Kweon
Kim Seung-Whan
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Abstract
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There are several studies that show hypothermia improves cellular ischemia damages on experimental and clinical bases. However, its exact molecular mechanisms are unclear. In this study, we demonstrate that hypothermia induced insulin-like growth factor 1 (IGF1) gene expression, and its expression was dramatically decreased under ischemic insults. It was also demonstrated that hypothermia activated endoplasmic reticulum (ER) stress sensors especially both the phosphorylation of eIF2α (eukaryotic translation initiation factor 2 alpha) and ATF6 (activating transcription factor-6) proteolytic cleavage. However, the factors of apoptosis and autophagy were not associated with hypothermia. We suggest that hypothermia-treated IGF1 gene expression after ischemia may show a good possibility for the development of treatments and diagnostic methods in cerebral ischemic damages.
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KEYWORD
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Insulin-like growth factor 1 (IGF1), Hypothermia, Ischemia, Endoplasmic reticulum (ER) stress sensor
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